Anyone that wants to build muscle mass has no doubt explored the growth hormone production benefits that SARMs provide. MK 677 Ibutamoren is a popular bulking SARM that is widely used among amateur and professional bodybuilders.
Many people believe Ibutamoren is a SARM (selective androgen receptor modulators) but this is not the case. MK 677 is actually a ghrelin receptor agonist.
As you may be aware, ghrelin is a hunger hormone. It’s manufactured in the intestines.
However, although the hormone’s relationship with hunger is generally its main claim to fame, there is a lot more to ghrelin than most people think.
The hormone ghrelin activates its receptor, growth hormone secretagogue receptor (GHS-R). By doing so, it not only increases appetite it also affects fat deposition and HGH release.
Let’s explore more about Ibutamoren MK 677 here.
What is Ibutamoren?
Ibutamoren is a growth hormone stimulant, and this is the main reason why Sylvester has such a body at the age of 70! Its levels of growth hormone are very high, which allows it to recover faster and also helps its body build new cells, which reverses the aging process. Ibutamoren increases the levels of the human growth hormone trictano and has great potential to help you achieve such a result.
Ibutamoren Mesylate is a substance that has been the subject of more discussions in online forums than actual clinical trials. However, the study so far supports several benefits of Ibutamoren related to its ability to increase growth hormone and IGF-1 levels. Ibutamoren is often discussed in online forums because of its anabolic properties on muscles. It is available as an organic agent to greatly increase growth hormone levels.
Ibutamoren (also known as ibutamor mesylate or MK-677) promotes the secretion of growth hormone (GH) and increases insulin-like growth factor 1 (IGF-1). It increases growth hormone levels by mimicking the action of the hormone ghrelin and binding to one of the ghrelin receptors (GHSR) in the brain.
Activated GHSR stimulates the release of growth hormone from the brain. GHSR is found in areas of the brain that control appetite, pleasure, mood, biological rhythms, memory and cognition. Therefore, we can expect that it may also affect these functions. The most sought after property of ibutamoren is that it increases growth hormone levels with little or no increase in other hormones, such as cortisol.
Cortisol suppresses the immune system, reduces wound healing, impairs memory, and the presence of high levels of cortisol is usually not desirable.
Ibutamoren Review
Ibutamoren Mesylate is a medication used to boost metabolism and bone strength. This compound has been associated with vast health benefits, but strangely, when you try to search it online, you are likely to come across more discussion forums about it than actual clinical trials. This, therefore, makes it somewhat challenging to tell what it can do with typical online propaganda.
In the few clinical studies we’ve seen so far, there are promising details that point towards the compound’s ability to improve Insulin growth factor 1 (IGF-1) and growth hormone levels.
When Ibutamoren is introduced into your body, it works similarly as the hormone ghrelin. The compound then attaches itself to the ghrelin receptors (GHSR) found in the brain. This activates the receptors stimulating the release of growth hormone from the brain.
GHSR is located in the brain areas tasked with controlling mood, biological rhythms, pleasure, appetite, cognition and memory. This has always been a subject of heated debates when discussing the effects of Ibutamoren on brain performance. Studies, however, show that the only thing affected by the presence of this compound in GHSR is an increase in appetite. So far no reliable studies have been able to show how MK-677 can influence the rise or decline of any of the other factors controlled in this part of the brain.
What makes using Ibutamoren fantastic is how it selectively influences an increase in growth hormone without affecting secretion of other hormones in the brain. Users of Mk-677 can hence safely take the drug without having to worry about whether levels of other hormones like cortisol (which reduces the effectiveness of the immune system) will increase.
How does Ibutamoren MK 677 work?
Ibutamoren Mesylate functions like a growth hormone pulse booster. As such, it is capable of influencing production and levels of the essential hormone in the body through various clinically proven ways:
- It stimulates your body to release more growth hormone releasing hormone or GHRH.
- As the levels of GHRH go high, the compound goes further to amplify signal transmission in the somatotrophs located in the anterior pituitary gland. This helps in increasing levels of growth hormone in the body.
One of the biggest reasons for the decrease in growth hormone levels in the body is the presence of somatostatin. When this chemical is released into the body it will not just slow down the release of growth hormone but can even go as far are stopping its release altogether. It also helps to inhibit the release of somatostatin and will also prevent or stop communication of somatostatin receptors thus blocking the expression of its effects.
Benefits of Ibutamoren MK 677
Improves Muscles Mass
Ibutamoren is an exceptional SARM substance. One of the biggest uses of MK 677 is for the bulking up of muscles. The compound can quickly be taken orally, and users only need to use it once a day to enjoy benefits such as an increase in muscle strength and mass and reducing body fat. Obese men can also experience an increase in lean mass and basal metabolic rate after just two months of using it.
Ibutamoren is often used as an anabolic substance to increase lean muscle mass. It is orally active and can be taken once a day. As mentioned earlier, it also increases growth hormone and IGF-1 levels. Both growth hormone and IGF-1, in turn, increase muscle mass, muscle strength and reduce body fat. In obese healthy men, two months of Nutrobal treatment increases lean mass and transiently increases basal metabolic rate (BMR).
Increase in Bone Density
An increase in growth hormone will naturally lead to improved bone density. This is, however, not something you’ll notice overnight or after just a few times of using Mk-677. It’s a long-term benefit that might even take up to a year to witness. Studies have shown that the use of MK 677 in healthy obese men led to improved bone turnover while elderly adults observed increased bone building. Post-menopausal women using Ibutamoren will also benefit from boosted bone mineral density that prevents osteoporosis and leads to an increase in bone strength.
Growth hormone (GH) increases bone metabolism and possibly bone density [R]. Ibutamoren is made for long-term use, so if used to strengthen bone structure, it takes a long time, more than 1 year, to see an increase in bone density. In healthy male volunteers, it increased bone metabolism [R]. In adults, ibutamoren increases bone structure as measured by osteocalcin, a marker of bone metabolism [R]. In postmenopausal women, ibutamoren increases bone mineral density, which helps increase bone strength and prevent osteoporosis.
Prevents Muscle Wasting
A decrease in proteins be it due to poor diet, or other issues can very quickly lead to muscle wasting. Ibutamoren will reverse such effects promoting gait speed and muscle strength in no time. In healthy individuals deprived of food, ibutamoren prevents the loss of protein caused by a low-calorie diet, and thus saves the individual from muscle degradation . In elderly patients with a hip fracture, Nutrobal MK677 improves gait speed, muscle strength and reduces the number of falls.
Promotes Quality Sleep
Your brain won’t be able to focus efficiently on the gym or any other activities if you are not getting sufficient sleep. Ibutamoren understands the importance of high-quality sleep, and that’s why the compound is also formulated to deliver that. This is a benefit backed by various clinical trials and further supported by multiple user testimonials online.
Can improve cognitive performance
There are reports that using Ibutamoren can deliver cognitive benefits but there are very limited studies to prove this. It is believed that since the compound affects ghrelin receptors that influence brain functioning using of MK-677 to impact the performance of these receptors could consequently improve your cognitive abilities. Mk-677 also increases levels of IGF-1 in the body a chemical that controls learning and memory, and this adds to the speculations that Ibutamoren has nootropic benefits. We, however, need more scientific studies to provide a direct link between Ibutamoren and brain performance.
Some people use ibutamoren to improve brain function because it acts on the ghrelin receptor, which has nootropic effects. Here are two indirect mechanisms by which ibutamoren can improve brain function. Ibutamoren increases IGF-1, which is known to improve memory [R, R]. Ibutamoren also increases the duration of deep sleep (REM) and the quality of sleep. And sleep is essential for good cognitive function .
Improves recovery
One study showed that in both younger and older individuals, ibutamoren improved the quality of sleep and the duration of REM sleep (rapid eye movements). In addition to research, there are many reports of improvements in sleep quality in various online forums. Many people neglect good sleep, and it is actually one of the biggest, if not the biggest factor in what results you will get in the gym. This is the biggest advantage of Ibutamoren MK677, it will allow you to recover quickly and achieve higher results in the gym, even without much sleep.
Provides anti-aging benefits
Once you hit your 30s going forward, the production of growth hormone starts declining. This is what results in cases such as loss of hair, skin elasticity, bone density, and many other effects. Since Ibutamoren increases levels of growth hormone in the body, the user will be able to enjoy better cell regeneration thus combating the effects of aging.
Growth hormone (GH) release and muscle mass decrease from mid-puberty and continue throughout life. In one study in elderly patients, ibutamoren increased GH and IGF-1 levels to those of healthy young adults without serious side effects [R]. IGF-1 is known to have beneficial effects on longevity. In another study, Nutrobal rejuvenated the growth hormone profile in obese patients.
Boosts tissue regeneration and wound healing
Tissue regeneration and the healing of wounds becomes problematic when we age, and this is partly due to low levels of growth hormone in the body. Once supplemented by a product like Ibutamoren, wounds will heal faster because the high levels of growth hormone enhance tissue regeneration.
Treating growth hormone deficiency
Growth hormone deficiency is quite a severe problem, especially in children. Ibutamoren has been used to treat this deficiency where it helps with increasing growth hormone, IGFBP-3, and IGF-1. What makes it even more ideal for use in children is that it’ll boost growth hormone levels without touching in glucose, thyroxine (T4), Triiodothyronine (T3), prolactin, insulin, cortisol or thyrotropin levels.
The compound can also be used to treat growth hormone deficiency in men where it works almost in a similar manner as it does in children except in adults, glucose, and insulin levels are also likely to be affected. Ibutamoren may increase growth hormone, IGF-1 and IGFBP-3 levels in children with growth hormone deficiency. In addition, these effects are achieved without altering the concentrations of prolactin, glucose, triiodothyronine (T3), (T4), thyrotropin , cortisol or insulin . In men and women with severe GH deficiency, ibutamoren increases IGF-1 and growth hormone without significant changes in cortisol, PRL and thyroid hormone levels. However, insulin and glucose increase.
How to Take Ibutamoren?
Ibutamoren is made for use in very long periods, ranging from 6 months to a year. But in case of intake in order to improve the physical condition and appearance of the body, the most popular method of intake is an interval of 8 to 12 weeks. Ibutamoren can be taken in packs of 20 to 50 mg per day, with a higher dose having the potential for faster results. There is no great benefit of exceeding the recommended dose of 50 mg.
Ibutamoren MK 677 Side Effects
Yes, usage of Ibutamoren has been associated with various side effects majority of which are similar to those experienced by people with excessive growth hormone in the body. These include; increase in appetite, muscle pain, and subtle lower extremity edema. A few studies also pointed out the possibility of seeing a decrease in insulin sensitivity, and an increase in blood glucose.
The most common side effects of ibutamoren are increased appetite and transient, mild swelling in the lower extremities and muscle pain. Several studies have shown an increase in blood glucose fasting and a decrease in insulin sensitivity . These side effects are similar to those seen in people with elevated levels of growth hormone, mainly joint pain and insulin resistance.
Although most studies showed few or no side effects, one study was discontinued due to serious side effects. In elderly patients with a hip fracture, increased blood pressure, blood sugar and HbA1c have been observed and there have been cases of congestive heart failure [R]. Patients with congestive heart failure are over 80 years of age and have a history of previous heart failure.
In elderly patients (at least 80 years old) cases of high blood glucose, pressure and HbA1c are also prevalent.
Users of Ibutamoren are advised to check their blood sugar and insulin levels regularly. Watching carbohydrate intake is also essential.
Cancer patients are discouraged from taking Ibutamoren as it can boost cancer growth. Th1 Dominant individuals should also stay away from Mk-677.
Clinical Research
So much is said about Ibutamoren, and that’s why we began by stating that it is rather difficult to differentiate what’s real from what isn’t. Going through the limited information available, we have fortunately discovered that benefits such as muscle growth and endurance are undebatable here.
This is why Ibutamoren is relied upon by hundreds of bodybuilders and athletes out there for their day-to-day performance. The fact that it can be utilized orally gives it an upper hand against typical steroids that demand injections. What’s even more brilliant is that unlike these steroids that leave people nursing severe side effects, Ibutamoren is much safer especially if used correctly.
For full disclosure, you should know that benefits such as treating osteoporosis, obesity and hip fractures are all still under investigations.
Concluding Ibutamoren Review
If you want to boost your endurance, energy, strength and bone density, then Ibutamoren is what you need. Maintaining muscle mass while on a low-calorie diet has never been any easier thanks to Ibutamoren MK-677. The compounds ability to increase your growth hormone levels will not just benefit you in the gym but will also help to keep you generally healthy. Ibutamoren stacks well with Ostarine.
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